University of Leeds Featured PhD Programmes
University of Kent Featured PhD Programmes
Catalysis Hub Featured PhD Programmes
University of Glasgow Featured PhD Programmes
University of Bristol Featured PhD Programmes

Dissecting cell complexity using super-resolution microscopy, one molecule at a time


About This PhD Project

Project Description

The stress response of sporulation in bacteria is a fantastically system for studying biophysics processes of emergent complexity. This project involves high resolution bioimaging studies in living bacteria of proteins involved in sporulation.

You will study sporulation as a model system to understand how structural and functional complexity emerges in living cells. We aim to understand the: (i) structure and function of proteins involves in regulating sporulation and forming channels between the spore and the mother cell; (ii) roles of the cell wall remodelling during spore formation engulfment. You will use, and develop, pioneering imaging approaches of in the Leake group enabling you to monitor spatiotemporal dynamics, kinetics and interactions of these processes in functional, living cells in real time, one molecule at a time.

This is particularly timely since we have acquired compelling preliminary single-molecule data from several new functional B. subtilis bacterial strains with significant progress in the required molecular biology underway: it is an ideal time to capitalize on these developments by performing extensive functional imaging and analysis combined with complementary new biochemical and genetics investigations.

References

The majority of decisions on funding for PhD positions will be made in March following interviews in February. Apply by 31 January 2019 to be considered for funding.

Related Subjects

Email Now

Insert previous message below for editing? 
You haven’t included a message. Providing a specific message means universities will take your enquiry more seriously and helps them provide the information you need.
Why not add a message here
* required field
Send a copy to me for my own records.

Your enquiry has been emailed successfully





FindAPhD. Copyright 2005-2019
All rights reserved.