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Dissecting novel mechanisms of cysteine protease biology in tumourigenesis

Project Description

Proteases are known for their role in facilitating tumour development, primarily through processes such as proliferation and invasion. This project will focus on examining novel mechanisms identified within our research group as contributing factors to tumourigenesis. We have identified that cysteine cathepsins can mediate transcriptional control of numerous factors including pro-inflammatory chemokines such as CCL2 (Wilkinson et al, 2015). We have also recently discovered a potential role for cathepsins in epigenetic regulation of breast cancer which we will evaluate further during this PhD project.

Funding Notes

Applicants should have a 1st or 2.1 honours degree (or equivalent) in a relevant subject. Relevant subjects include Pharmacy, Molecular Biology, Pharmaceutical Sciences, Biochemistry, Biological/Biomedical Sciences, or a closely related discipline. Students who have a 2.2 honours degree and a Master’s degree may also be considered, but the School reserves the right to shortlist for interview only those applicants who have demonstrated high academic attainment to date

How good is research at Queen’s University Belfast in Allied Health Professions, Dentistry, Nursing and Pharmacy?

FTE Category A staff submitted: 33.00

Research output data provided by the Research Excellence Framework (REF)

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