About the Project
The aim of this project is to dissect the effects of these mutations on gene function to better understand the molecular mechanisms underlying brain development and language disorders. The candidate will use a multidisciplinary approach that combines human genetics, functional genomics, cell biology and biophysics. Different cellular model will be generated using CRISPR/Cas9 genome editing system. These models will then be characterised taking advantage of the outstanding imaging facilities available in St Andrews. We will study the effects of these mutations on ion homeostasis using electrophysiological approaches. In parallel, we will screen larger cohorts of children with language difficulties targeting ion transporters genes.
The ideal candidate will have an interest in neurodevelopmental disorders. While training will be provided, previous experience in human genetics and molecular biology is desirable.
For further details on the project and informal enquiries please contact to Dr. Silvia Paracchini ([Email Address Removed] ) with a CV and a covering letter.
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