About the Project
The O’Neill laboratory at Leeds is actively pursuing several complementary approaches to better understand and address this phenomenon, and has a particular focus on understanding the mechanisms that allow ’superbugs’ to resist the effects of antibiotics. We are currently looking for a talented and motivated prospective PhD candidate to join us in this endeavour, who will work to elucidate the molecular detail of several antibiotic resistance mechanisms found in the major human pathogen, Staphylococcus aureus.
Please see the O’Neill lab website for more information about what we do, and links to our published work:
(1) Sharkey, LK; Edwards, TA; O'Neill, AJ (2016) ABC-F proteins mediate antibiotic resistance through ribosomal protection. mBio, 7: e01975-15
(2) Randall, C; Gupta, A; Jackson, N; Busse, D; O'Neill, AJ (2015) Silver resistance in Gram-negative bacteria: a dissection of endogenous and exogenous mechanisms J Antimicrobial Chemother, 70: 1037-1046
(3) Cox, G; Thompson, GS; Jenkins, HT; Peske, F; Savelsbergh, A; Rodnina, MV; Wintermeyer, W; Homans, SW; Edwards, TA; O'Neill, AJ. (2012) Ribosome clearance by FusB-type proteins mediates resistance to the antibiotic fusidic acid. Proc Natl Acad Sci U S A 109 2102-7
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