Dissecting the regulation of localised protein synthesis during angiogenesis

Angiogenesis, or the emergence of new blood vessels, is a complex biological process that involves the coordinated migration of endothelial cells. As they navigate through tissues, leading endothelial cells present at the tip of new sprouting vessels are guided by signalling molecules. These cues are critical modulators of the molecular and cellular responses triggered during angiogenesis. Amongst other factors, messenger (m)RNAs are asymmetrically distributed in motile endothelial cells. Some of these mRNAs are transported to the front of tip endothelial cells where they actively participate in cell motility.

We are looking for a highly motivated and enthusiastic student to embark on a PhD project that addresses fundamental questions in the fields of messenger RNA localisation and local translation in the context of angiogenesis. You will take advantage of a wide range of cell culture techniques, advanced microscopy an molecular biology approaches designed to explore how and why particular mRNAs are translated into proteins at the front of endothelial cells.

Your studies will be carried out in a collaborative environment under the supervision of WWIEM and PGJCCR researchers, and your findings will shed light on novel therapeutic targets to treat vascular-related disorders. 

ENTRANCE REQUIREMENTS

The minimum academic requirement for admission to a research degree programme is normally an Upper Second Class Honours degree from a UK or ROI HE provider, or an equivalent qualification acceptable to the University. Further information can be obtained by contacting the School.

International Students

For information on international qualification equivalents, please check the specific information for your country.

English Language Requirements

Evidence of an IELTS* score of 6.5, with not less than 5.5 in any component, or an equivalent qualification acceptable to the University is required. *Taken within the last 2 years.

International students wishing to apply to Queen's University Belfast (and for whom English is not their first language), must be able to demonstrate their proficiency in English in order to benefit fully from their course of study or research. Non-EEA nationals must also satisfy UK Visas and Immigration (UKVI) immigration requirements for English language for visa purposes.

For more information on English Language requirements for EEA and non-EEA nationals see: www.qub.ac.uk/EnglishLanguageReqs.

If you need to improve your English language skills before you enter this degree programme, INTO Queen's University Belfast offers a range of English language courses. These intensive and flexible courses are designed to improve your English ability for admission to this degree.