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Diversity Oriented Synthesis of Chiral Saturated Heterocycles: A New Approach to a Screening Collection of Fragment and Lead-like Compounds

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  • Full or part time
    Dr James Bull
    Prof A Spivey
  • Application Deadline
    No more applications being accepted
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

Applications are sought from exceptional candidates for a fully funded 4-year PhD studentship in synthetic organic chemistry starting October 2016. The successful candidate will join the labs of Dr James Bull ( at Imperial College London and be jointly supervised by Dr Bull, Prof Alan Spivey and Dr Christopher Cordier.

This project will involve the development of a diversity oriented synthesis process to prepare chiral saturated heterocycles with diverse substitution, in a new approach to screening collections of fragment and lead-like compounds. It builds upon recently published work from the group (Angew. Chem. Int. Ed. 2014, 53, 12559; Chem. Commun. 2015, 51, 15446; also see Chem. Commun. 2014, 50, 5203 Org. Lett. 2014, 16, 4956). The project will provide excellent training in multi-step synthesis, the development of new catalytic reactions, and the design of biologically relevant compounds.

This position would suit an ambitious and highly motivated researcher with interests in synthetic and medicinal chemistry, and will be suitable for candidates wishing to pursue a career in academia or industry. A strong background in synthetic organic chemistry is essential, with previous research experience in industrial or academic laboratories desirable.

Funding is available to students with UK residency status and will cover tuition fees and provide a tax-free stipend including a London allowance. Applicants should hold (or expect to be awarded) a first class Masters degree in Chemistry.

How to apply
Interested candidates are encouraged to make informal contact with Dr Bull by email ([Email Address Removed]), sending a CV and letter of motivation as soon as possible.

Formal applications should be made through the Imperial College online application process, which can be accessed via the following link:
Please mention Dr Bull in the Proposed Supervisor field and make reference to the above project title in the Proposed Research Topic field. Short-listed candidates will be required to attend an interview in person at Imperial College London.

The closing date for formal applications is 12th February 2016

Imperial College London is a world-class research institution. The Department of Chemistry offers exceptionally well equipped laboratories and a thriving, modern multidisciplinary research environment. Further information on the Department of Chemistry can be found at the following web page:

Funding Notes

The studentship is funded by AstraZeneca and EPSRC, and will to include a placement in AstraZeneca research laboratories.

How good is research at Imperial College London in Chemistry?

FTE Category A staff submitted: 54.90

Research output data provided by the Research Excellence Framework (REF)

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