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DNA display of small molecules

  • Full or part time
  • Application Deadline
    Thursday, February 21, 2019
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

Synthesis of hypermodified DNA stretches will be developer based on polymerase incorporation of combinations of 2, 3 and 4 modified nucleotides bearing selected biologically relevant small molecules (peptides, sugars, drugs etc.) as substituents. The resulting monodisperse oligo- and polymers will be based on DNA scaffold bearing the small molecules at precisely defined positions and combinations. Hybridization and folding of these oligo- and polymers will be studied as well as their interactions with proteins and biological activity.

How to apply

To apply for a PhD study at IOCB Prague, you must hold a Master’s degree (MSc) or the equivalent of the MSc in similar field (four or five year undergraduate degree). The application can be submitted before obtaining the Master’s degree, however, the applicant should obtain the degree within five months after the application deadline.

For more information visit our website “Call for PhD applications 2019”:
https://www.uochb.cz/web/structure/797.html

You can apply online via our application form http://www.uochb.cz/phdapplication/index.php/PhDrecruitment

Enquiries

All general enquiries should be directed to Katerina Solcova (). Scientific enquiries can be addressed to the supervisor ().

Funding Notes

1. Hocek, M.: "Synthesis of Base-Modified 2'-Deoxyribonucleoside Triphosphates and Their Use in Enzymatic Synthesis of Modified DNA for Applications in Bioanalysis and Chemical Biology" J. Org. Chem 2014, 79, 9914 – 9921.

References

Regular monthly income of students at IOCB Prague varies depending on the faculty scholarship and supervisor's financial options.

Related Subjects

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