About the Project
The influence of age on oral bacterial communities is minimally explored and how these evolving communities tune immune function is unknown. This is an oversight, as advancing age is accompanied by failure of oral barrier immune-homeostasis, resulting in increased incidence and severity of oral inflammation, particularly periodontitis. Critically, periodontitis is a risk factor for multiple disorders promoting unhealthy ageing, including cardiovascular disease and diabetes. Therefore, elucidating factors driving loss of oral barrier immune-homeostasis and development of inflammation is urgently required.
We hypothesize that an altered host-microbe dialogue promotes dysregulation of oral barrier immune responses with age. This project will outline how oral bacterial communities are remodelled during ageing and, importantly, the influence of this altered bacterial community on oral barrier immune functions. Collectively this work will further our understanding of how oral barrier inflammation arises with age, promoting development of therapeutics to reinforce oral barrier immune-homeostasis across a life-course.
Informal enquiries may be made directly to the primary supervisor.
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