We will build a novel sensing toolbox alongside suitable analytical tools to image biomarkers of cell function in real time. We will prepare a new platform of multiplexed photonic biosensors that will be able to image pathogens (bacteria, virus) in infection models of increasing complexity. We will optimise the sensors in cell cultures and validate selected sensors for bioimaging in different fluorescence-based imaging modalities, from super-resolution microscopy, FLIM and hyperspectral imaging. We will prepare for commercial readiness of the selected biosensors together with Tocris enabling us to move this technology into new commercial assets. Our main aim is to develop a collection of biomarkers to characterise photonic signatures of cellular function and translate them into a decision-making tool for sensing of infectious diseases, including multi-drug resistance.
We expect that the student will be trained by the supervisory team on the following:
- Development of a platform of multiplexable
- Analytical tools including data mining skills and
- Optical fingerprinting of fluorescent biosensors using different modalities, from super-resolution to
- Cell culture and fluorescence microscopy in live
- Participation in the development of marketing strategy through competitive landscape and future emerging
- Study IP landscape and freedom to Secure emerging IP, including paper and patent writing.
- Communication skills
The student will be accommodated (both lab and office space) at the Institute for Regeneration and Repair (IRR). The IRR is a world-class research institute at the interface of biological and medical sciences, with multidisciplinary groups with expertise on bioimaging and infectious diseases. The IRR also holds outstanding microscopy facilities and is next to the Royal Infirmary of Edinburgh hospital, maximising future translational opportunities. The project is mostly lab based with occasional data analysis.
CDT Essential Criteria
A Masters level degree (MEng, MPhys, MSc) at 2.1 or equivalent.
Desire to work collegiately, be involved in outreach, undertake taught and professional skills study.
Project Essential Criteria
Fluorescence spectroscopy, analytical and organic chemistry, microscopy.
CDT Desirable Criteria
Biological assays, super-resolution microscopy, FLIM, hyperspectral imaging.
The CDT
The CDT in Applied Photonics provides a supportive, collaborative environment which values inclusivity and is committed to creating and sustaining a positive and supportive environment for all our applicants, students, and staff. For further information, please see our ED&I statement: https://bit.ly/3gXrcwg.
Forming a supportive cohort is an important part of the programme and our students take part in various professional skills workshops, including Responsible Research and Innovation, and attend outreach training.
Continue with Facebook
