Project Description: An EngD project involving Gabriel Reines March completed in September 2019. The purpose of this project is to continue the work in multi-modality image registration through to a validation stage.
The previous project developed approaches to align CT, PET images to pathology images. The project used a deformable image modelling technique to register multi-modality images – CT, PET with pathological images in order to investigate tumour hypoxia with various PET tracers. Accurate and reliable image registration enable the escalation of radiotherapy doses to areas of known hypoxia.
The next phase of the project is validation of the protocol and algorithm that has been developed over the last 3 years. This requires a new cohort of patients and data from 4D PET-CT images. The algorithms and PET data will then be used to create a map of the tumour, allowing the clinical oncologist to more accurately plan radiotherapy. We aim to delineate identifiable histological areas on the images corresponding to: malignant cells, fibrosis, necrosis, inflammation, the boundary between normal tissue and tumour etc. Digital image processing techniques will be further refined to improve accuracy of registration and will also be used to automatically generate indicators related to the histological areas mentioned above.
Essential Criteria Good programming skills Experience in image processing and graphics Strong motivation Excellent Communication skills
Desirable Criteria Knowledge of medical imaging modalities
Company Information The EngD student will be based at the West of Scotland PET Centre. This is one of the busiest PET Centres in the UK with on site cyclotron (GE PET Trace 6), associated laboratories and 2 clinical PETCT scanners. Whilst the centre currently houses a GE Discovery 690 and GE Discovery 710 PETCT scanner, the former will be renewed in 2021 with a state of the art digital PETCT.
Medical, scientific and technological staff are based in the centre facilitating multidisciplinary support for research activities. The PET department is co-located with the Beatson West of Scotland Cancer Centre. The cancer centre is the second biggest department in the United Kingdom and provides radiotherapy and systemic anticancer treatment to a catchment population of 2.6 million people.
The Pathology department is located at the Queen Elizabeth University Hospital, it is the largest pathology department in the UK and is a centre for diagnostic digital pathology. It has close working ties with both of the above departments in order to support this exciting interdisciplinary research project. The University has fully equipped laboratory and library facilities to support the student.
Flexible Research Working As an equal opportunity employer we open to discuss Flexible Working arrangements
EngD Stipend of approximately £20,000 plus fees paid.