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Drivers of epithelial growth and repair in tissue-specific differentiation programmes

Project Description

Epithelial tissues are found at interfaces between the body and external environment and show site-specific functions, such as nutrient absorption by the gut and urinary barrier defence by the bladder. In addition to acquiring specialised morphologies and distinct apical surface features, epithelial tissues are differentially programmed at the cellular level to define other tissue-specific characteristics such as turnover rates and repair strategies. We have been defining the transcriptional programmes associated with bladder epithelial (urothelial) cell differentiation in vitro and found evidence of a significant reorganisation of the signal transduction circuitry. Using a well-characterised and experimentally tractable differentiated normal cell/tissue culture system, the project will employ state-of-the-art phosphoproteomic approaches to identify key receptor tyrosine kinase pathways in epithelial growth and repair. The results will be applicable to approaches in Tissue Engineering and Regenerative Medicine and should in the long term help identify new drug target candidates and therapeutic approaches for age-related chronic conditions affecting the bladder and associated urinary tract.

Funding Notes

This studentship is fully funded by York Against Cancer and covers: (i) a tax-free stipend, (ii) research costs, and (iii) tuition fees at the UK/EU rate. The studentship is available to UK and EU students only.

How good is research at University of York in Biological Sciences?

FTE Category A staff submitted: 44.37

Research output data provided by the Research Excellence Framework (REF)

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