Liver diseases are becoming a significant medical burden, due to the lack of donors and the high cost of therapy. This project aims to exploit a long-term culture system that maintains hepatocyte specific functions and cell viability for liver regeneration using self-assembled peptide hydrogels to mimic the normal hepatic extracellular matrix. The hydrogels can be modified to control cell responses and optimal gels will be characterised for hepatocyte, and other relevant cell behaviour (using biochemical assays, immunocytochemistry/imaging and gene and protein expression) with a view to tissue engineering and the development of in vitro 3D culture models.
Admissions qualifications / requirements
Relevant biomaterials / bioengineering / regenerative medicine experience
Equality, diversity and inclusion is fundamental to the success of The University of Manchester, and is at the heart of all of our activities. We know that diversity strengthens our research community, leading to enhanced research creativity, productivity and quality, and societal and economic impact. We actively encourage applicants from diverse career paths and backgrounds and from all sections of the community, regardless of age, disability, ethnicity, gender, gender expression, sexual orientation and transgender status.
We also support applications from those returning from a career break or other roles. We consider offering flexible study arrangements (including part-time: 50%, 60% or 80%, depending on the project/funder).