Coventry University Featured PhD Programmes
Xi’an Jiaotong-Liverpool University Featured PhD Programmes
Cardiff University Featured PhD Programmes

Dual HepC hepacivirin and HIV-1 proteases phosphorus-based inhibitors


Department of Chemistry

About the Project

Application Deadline:
Open until the position is filled

Requirements:
The candidate should have a first class or upper second class honours degree, or a master’s degree (or equivalent qualification), in Chemistry. Evidence of good spoken and written English is essential. The candidate should have an IELTS score of 6.5 or above, if the first language is not English. This position is open to all qualified candidates irrespective of nationality.

Degree:
The student will be awarded a PhD degree from the University of Liverpool (UK) upon successful completion of the program.

Project Description:
Hepatitis C virus is the cause of Hepatitis C, a major infectious disease that induces liver inflammation and cirrhosis. Recently, the first generation of Directly Acting Antivirals has been developed, which inhibit specific virus enzymes, with the main target being NS3/4A protease. The high co-occurrence of HepC/HIV infection prompted us to investigate the possibility of developing dual inhibitors for the HIV-I and NS3/4A proteases, i.e. targeting both diseases at one stroke. HIV/AIDS is one of the most devastating global diseases, with proteolytic processing of the viral polyprotein responsible for the generation of the mature, infectious species. Based on these facts, and given the remarkable properties of the phosphinic binding group, we have set out to develop enzyme inhibitors based on phosphinic peptides, which would simultaneously target the NS3/4A protease of HepC and the HIV-1 protease. Our preliminary results are highly encouraging.

For more information about doctoral scholarship and PhD programme at Xi’an Jiaotong-Liverpool University (XJTLU): Please visit
http://www.xjtlu.edu.cn/en/study-with-us/admissions/entry-requirements http://www.xjtlu.edu.cn/en/admissions/phd/feesscholarships.html

How to Apply:
Interested applicants are advised to email (XJTLU principal supervisor’s email address) the following documents for initial review and assessment (please put the project title in the subject line).
• CV
• Two reference letters with company/university letterhead
• Personal statement outlining your interest in the position
• Proof of English language proficiency (an IELTS score of 6.5 or above)
• Verified school transcripts in both Chinese and English (for international students, only the English version is required)
• Verified certificates of education qualifications in both Chinese and English (for international students, only the English version is required)
• PDF copy of Master Degree dissertation (or an equivalent writing sample) and examiners reports available

Informal enquiries may be addressed to Dr. Magdalini Matziari (), whose personal profile is linked below,
https://www.xjtlu.edu.cn/en/staff?department=chemistry&alias=magdalini-matziari

Funding Notes

The PhD studentship is available for three years subject to satisfactory progress by the student. The award covers tuition fees for three years (currently equivalent to RMB 80,000 per annum) and provides a monthly stipend of 5,000 RMB as a contribution to living expenses. It also provides up to RMB 16,500 to allow participation at international conferences during the period of the award. It is a condition of the award that holders of XJTLU PhD scholarships carry out 300-500 hours of teaching assistance work per year. The scholarship holder is expected to carry out the major part of his or her research at XJTLU in Suzhou, China. However, he or she is eligible for a research study visit to the University of Liverpool of up to three months, if this is required by the project.

Email Now

Insert previous message below for editing? 
You haven’t included a message. Providing a specific message means universities will take your enquiry more seriously and helps them provide the information you need.
Why not add a message here

The information you submit to Xi’an Jiaotong-Liverpool University will only be used by them or their data partners to deal with your enquiry, according to their privacy notice. For more information on how we use and store your data, please read our privacy statement.

* required field

Your enquiry has been emailed successfully





FindAPhD. Copyright 2005-2020
All rights reserved.