Dynamic Multi-Component Assembly of Nano-Cages in Solution

The research project will investigate the constitutional dynamic chemistry of hydroxamic acids resulting in assembly of multiple (organic and/or metal) components into dynamic libraries of ordered nano-cage structures with applicability in drug delivery, porous materials and supramolecular catalysis. This will entail the development of exciting novel dynamic organic chemistry and stereochemistry of hydroxamic acid metal coordination. The interest in self-assembly of cage compounds has progressed from design rules in the 90’s to Host:Guest chemistry in the 21st century and now moves forward looking towards structure:function correlations. The Lloyd group is developing dynamic chemistry of hydroxamic acids involving both stereochemical covalent and coordination chemistry. The project thus aims to utilise solution studies of this dynamic chemistry to understand the self-assembly of the cages and their function produced through the sum of the multiple components’ functionalities. This function will be studied through Host:Guest chemistry utilising fluorescence, UV/Vis spectroscopy, HPLC, crystallography and NMR.

You should have, or expect to receive, a First class or 2:1 MChem degree in Chemistry, or equivalent in a relevant related subject.

The Institute of Chemical Sciences (ICS) is an excellent environment for PhD research, with a thriving community of academics, post-doctoral and PhD researchers. ICS has many links to the other research institutes within the overall umbrella of the School of Engineering and Physical Sciences, providing a strong interdisciplinary theme to our research. Heriot-Watt occupies an attractive campus site on the outskirts of Edinburgh, with excellent public transport links to the centre of one of the Europe’s most exciting cities.