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Dynamics and regulation of ER-peroxisome contact sites

  • Full or part time
  • Application Deadline
    Sunday, February 17, 2019
  • Funded PhD Project (Students Worldwide)
    Funded PhD Project (Students Worldwide)

About This PhD Project

Project Description

The PERICO research programme aims to uncover how a central metabolic organelle, the peroxisome, participates in controlling cellular metabolism. Metabolism and metabolic control are emerging as important frontiers in physiology. This is because, in our rapidly changing world, we face the effects of both metabolic extremes – from obesity on the one hand to malnutrition on the other. Learning how to control energy metabolism is therefore one of the most pressing challenges of the 21stcentury.

Peroxisomes are key metabolic organelles, which must communicate and interact extensively with their environment to exchange metabolites and coordinate cellular responses. Membrane contact sites (MCS), where membranes of two organelles are physically tethered to enable rapid transfer of small molecules, enable organelle communication and are crucial for coordination of cellular functions and hence human health. Research on organelle interactions and communication is a challenging, upcoming field in current cell biology.

PERICO will exploit recent developments in high-throughput and genome-wide screening technologies, combine these with modern molecular cell biology and systems biology and ultimately translate the data into new leads for drug discovery and therapy.

Early Stage Researchers

The training schemes include specific research projects, secondments to partner organizations, a wide range of dedicated courses, and workshops organized by the academic and industrial partners of the Network. The scientific training programme will be complemented with training in managerial soft skills.

The positions for Early Stage Researchers are available for candidates with a research experience ≤ 4 years (counted from the diploma that gives the rights to embark in a doctoral degree).

Candidates must not have resided or carried out their main activity (work, studies, etc) in the country of their host organisation for more than 12 months in the 3 years immediately prior to recruitment (short stays, such as holidays, are not taken into account).

Requirements

Candidates should have:
• exceptional academic performance, including qualifications, prizes
• subject specific skills and expertise (see project descriptions)
• communication, presentation skills and team working abilities
• competence in written and spoken English.

Length of appointment: 3 years
Type of contract: temporary
Starting date: April 1, 2019
Applicants can apply for multiple positions.

Reference: ESR8-DE

A PhD position is available at the University of Freiburg, Department of Biochemistry & Functional Proteomics, Freiburg, Germany

Project title: Dynamics and regulation of ER-peroxisome contact sites

Description:
• Mapping of in vivo phosphorylation sites in Pex30p-dependent ER-peroxisome contact sites (EPCONS) under different conditions in yeast using high-resolution mass spectrometry.
• Identification of kinases mediating phosphorylation events and their preferred target sites to decipher the cellular signalling pathway(s) regulating EPCON formation.
• Functional analysis of EPCONS using site mutants of selected proteins mimicking or preventing phosphorylation or targeting selected protein kinases and signalling pathways using conditional mutant strains or specific kinase inhibitors.
• Characterizing human PEX30 and its role for the formation of EPCONS.

Location: Freiburg, Germany
Supervisor: Prof. Dr. B. Warscheid (bettina.warscheidATbiologie.uni-freiburg.de)
Co-supervisors: Prof. Dr. L.R.B. Schomaker, Lambert Instruments & Prof. Dr. I.J. van der Klei, University of Groningen
Planned secondments: University of Exeter, Lambert Instruments, University of Groningen
Required subject specific skills and expertise: a master’s degree in biology, biochemistry or a related discipline. Experience in proteomics/mass spectrometry and molecular genetics is advantageous but not mandatory.
Application deadline: 17/02/2019
Starting date: April 1, 2019

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