Dysregulated fatty acid trafficking in the pathogenesis of type 2 diabetes: a study of Black-British and White-European men
To start: 1 September 2020
Award: A 3 year PhD studentship
School: School of Life Course Sciences
Supervisors: Dr Louise Goff and Dr Martin Whyte
Study mode: Full time
Ethnicity is a risk factor for type 2 diabetes (T2D). In the UK, T2D is 3-5 times more prevalent among individuals of Black African ethnicity than White Europeans. Tackling the cause(s) for T2D in Black African communities is a priority.
T2D develops at lower body mass index (BMI) in Black African than White European adults. Fat tissue within the abdomen (visceral adiposity) is a risk factor for diabetes in White Europeans. Yet Black African populations have lower levels of visceral fat, despite greater insulin resistance. Possibly because of low visceral adiposity, Black Africans also have lower fasting lipids (triacylglyercol, TAG).
There is persuasive evidence that postprandial lipaemia is a more important determinant of cardiometabolic risk than fasting lipids. Notably, this understanding comes largely from studies in White-Europeans. Until recently, there have been no investigations conducted in ethnic minority groups to understand the extent to which adverse post-prandial fat handling is responsible for the disproportionate cardiometabolic risk that ethnic minority groups experience.
Post-prandial lipaemia is proposed to be a more important determinant of cardiometabolic risk than fasting lipids and may be responsible for the disproportionate cardiovascular risk experienced by BAME groups.
This PhD will employ highly sophisticated techniques to study post-prandial fat handling and metabolism using stable isotopes, undertaking a comparison between men of Black African and White European ethnicity.
How to apply:
To apply: please visit the King’s Apply website and follow the steps outlined below:
Register a new account and login.
Open a new application.
Select the programme: “Life Course Science Research MPhil/PhD” (Full-time)’.
Complete and submit your application noting the following:
· Include name of First Supervisor
· Include a supporting personal statement
· 2 References · CV
· Funding –select drop-down ‘4. Grant Awarding Body’. For the award status, select ’Advertised Scholarship’.
· Reference number: JRC2020_02
English Language Requirements:
IELTS 7.5 overall with a minimum of 7.0 in each skill. Please refer to King’s English language requirements.
Sponsor: King's Medical Research Trust
Stipend: £17,000 per annum