The formation of the brain involves a complex choreography of events and players during development. While this process is continuous, there are however critical periods in which this process is particularly susceptible to perturbations. These perturbations can alter the transcriptional profiles of the various cell types in the developing cortex which in turn can have a long-lasting impact over the lifespan of the organism. This project will focus on the brain immune cells, microglia. Microglia are known to be involved in a myriad of neurodevelopmental processes ranging from the removal of cell debris, secretion of proliferative and survival signals to the formation and removal of synapses[1]. Alterations in their developmental trajectories, especially during these critical periods, have been linked to altered mice behaviour and function[2].
The impact of alteration of microglia development in later life, however, is unknown. Consequently, the main aim of this project is to study the link between the development of microglia in mice and how changes in their development may influence their responses in stroke later in life. More specifically, this project aims to look at the transcriptional changes of microglia using the appropriate experimental paradigms. This project will take advantage of both laboratories’ expertise – the Wong’s lab on early postnatal development and the Allan lab’s experience on neuroinflammation and neurological disorders such as stroke. We will use a multidisciplinary approach such as fixed and live cell imaging, transcriptomics and molecular biology to unravel the mechanisms as to how development can shape microglial responses in neurological disorders such as stroke.
Eligibility
Applicants must have obtained or be about to obtain a First or Upper Second class UK honours degree, or the equivalent qualifications gained outside the UK, in Neuroscience or Molecular/Cellular/Developmental Biology or a relevant subject area. Applicants with previous laboratory experience in neuroscience are encouraged to apply.
Before you Apply
Applicants must make direct contact with preferred supervisors before applying. It is your responsibility to make arrangements to meet with potential supervisors, prior to submitting a formal online application.
How to Apply
For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website (https://www.bmh.manchester.ac.uk/study/research/apply/). Informal enquiries may be made directly to the primary supervisor. On the online application form select the appropriate subject title - PhD Neuroscience.
For international students, we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences. For more information please visit https://www.bmh.manchester.ac.uk/study/research/international-phd/
Your application form must be accompanied by a number of supporting documents by the advertised deadlines. Without all the required documents submitted at the time of application, your application will not be processed and we cannot accept responsibility for late or missed deadlines. Incomplete applications will not be considered. If you have any queries regarding making an application please contact our admissions team [Email Address Removed]
Equality, Diversity and Inclusion
Equality, diversity and inclusion is fundamental to the success of The University of Manchester, and is at the heart of all of our activities. The full Equality, diversity and inclusion statement can be found on the website https://www.bmh.manchester.ac.uk/study/research/apply/equality-diversity-inclusion/
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