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EASTBIO Advanced model-based optimization of biomolecular systems.

  • Full or part time
    Dr D Oyarzun
  • Application Deadline
    Sunday, January 05, 2020
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

We are looking for an excellent doctoral student to join us on a project at the interface of computational optimization and synthetic biology. Successful candidates will join the Biomolecular Control Group
( led by Diego Oyarzún. Our team develops model-based methods and theory applied to biotechnology ( and biomedicine (, Large parts of our theoretical work are in collaboration with wetlab partners in the UK, Europe and the USA.

The project will focus on model-based optimization of cell metabolism and gene regulatory circuits. We will use computational optimization to study robust regulatory architectures that can be built with synthetic biology techniques. We will apply the results to key challenges in bioproduction and synthetic biology, using multiobjective optimization to find optimal gene circuit architectures that trade-off competing design goals. These methods will feed into a design-built-test-learn cycles for strain design and optimization.

The Biomolecular Control Group is co-located at the School of Biological Sciences and School of Informatics of the University of Edinburgh. This gives us privileged access to cutting-edge biological research at Edinburgh, as well as its world-leading expertise in machine learning and data science. Our students will benefit from this unique synergy and also enjoy the thriving ecosystem of SynthSys – the Edinburgh Centre for Systems and Synthetic Biology.

Ideal candidates should have excellent academic record and passion for quantitative methods in the life sciences and medicine. We seek open-minded and creative students keen to join a multidisciplinary team. You should have excellent mathematical and computational skills, as well as outstanding presentation skills for various audiences. Applicants must hold a First Class or an Upper Second Class degree (or equivalent overseas qualification) in a discipline relevant to the project, such as Control Theory, Biotechnology, Applied Mathematics, Computer Science and Physics.

Funding Notes

The “Visit Website” button will take you to our Online Application checklist. Complete each step and download the checklist which will provide a list of funding options and guide you through the application process. Follow the instructions on the EASTBIO website (you will be directed here from our application checklist), ensuring you upload an EASTBIO application form and transcripts to your application, and ticking the box to request references. Your referees should upload their references using the EASTBIO reference form, in time for the 5th January deadline so please give them plenty of time to do this by applying early.

How good is research at University of Edinburgh in Biological Sciences?

FTE Category A staff submitted: 109.70

Research output data provided by the Research Excellence Framework (REF)

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