About the Project
Our team recently pioneered discoveries that demonstrate SA employs the small post-translational modifier, ubiquitin, to establish durable immunity. SA induces dynamic modification of regulatory proteins with ubiquitin chains of diverse linkage types, generating the potential to control their functions and activities. Understanding the relevance of distinct ubiquitin chain topologies and their protein targets is a major challenge and is only in its infancy in plants. In this project you will utilise proteomic, genomic and biochemical approaches to investigate how SA-induced ubiquitin signalling engages the transcriptional machinery, orchestrates chromatin permissiveness to allow gene expression, and utilises diverse chain linkage types to establish durable broad-spectrum immunity. In addition to advancing fundamental insights into dynamic ubiquitin signalling, this ambitious project will reveal how ubiquitin signalling can be harnessed to revolutionise plant protection strategies.
The School of Biological Sciences is committed to Equality & Diversity: https://www.ed.ac.uk/biology/equality-and-diversity
How to Apply:
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