About the Project
In this project, we wish to extend our studies into looking at the effects of Willin/FRMD6 on primary neuronal differentiation but also synaptic activity. To uncover the latter question, we will use another novel optical based technology which we have developed, where we can measure the connectivity of a neuronal network in a new high throughput optogenetics technique (DOI: 10.3389/fnins.2018.00451). We will also utilise our bespoke advanced optical microscopy that we have previously developed including novel light sheet and super-resolution microscopy. By utilising this blend of cutting-edge optical technology, we will be able to identify how Willin/FRMD6 can change neuronal development. More recently Willin/FRMD6 has also been shown potentially to be involved in neurodegeneration, as such our studies will under-pin the understanding of the fundamental mechanisms involved in these processes. As indicated above, the successful candidate will develop a wide range of highly sought-after interdisciplinary skills from culturing primary neuronal cells (including brain slice), through to biochemistry and advanced optical technologies.
In order to apply for this position, please follow the application instructions under http://www.eastscotbiodtp.ac.uk/how-apply-0 to obtain the EASTBIO Application form.
Then, submit the EASTBIO application form and your academic transcripts as part of a formal online application- https://www.st-andrews.ac.uk/study/apply/postgraduate/research/
In the online application form, you will be asked to provide contact details for two academic references. Please ask your referees to use the EASTBIO reference form provided under the link above when preparing their support letter, and to ensure references are provided by the deadline on 6 January 2021.
This opportunity is open to UK and International students and provides funding to cover stipend and UK level tuition. For international candidates, the University of St Andrews will cover the Home-International fee difference. Please refer to UKRI website and Annex B of the UKRI Training Grant Terms and Conditions for full eligibility criteria.
Angus L, Moleirinho S, Herron L, Sinha A, Zhang X, Niestrata M, Dholakia K, Prystowsky MB, Harvey KF, Reynolds PA, Gunn-Moore FJ.
Oncogene. 2012 31(2):238-50.
All-Optical Assay to Study Biological Neural Networks.
Afshar Saber W, Gasparoli FM, Dirks MG, Gunn-Moore FJ, Antkowiak M.
Front Neurosci. 2018 12:451.
Willin/FRMD6 Influences Mechanical Phenotype and Neuronal Differentiation in Mammalian Cells by Regulating ERK1/2 Activity
Kronenberg N, Tilston-Lunel A, Thompson F, Chen D, Yu W, Dholakia K, Gather M, Gunn-Moore FJ
Front Cell Neurosci. 2020
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