EASTBIO: Structure and function of ER export receptors at University of Dundee on FindAPhD.com

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Dr Liz Miller No more applications being accepted Competition Funded PhD Project (UK Students Only)

Dundee United Kingdom Biochemistry Biophysics Cancer Biology Developmental Biology Genetics Molecular Biology

About the Project

Protein secretion is initiated in the endoplasmic reticulum (ER) by capture of nascent proteins into COPII vesicles. Many proteins require cargo receptors to gain access to these vesicles. Cargo receptors cycle between the ER and Golgi, binding their clients in the ER and releasing them in the Golgi. We aim to understand the mechanisms that drive such context-specific interaction, and how client binding influences engagement with the vesicle formation machinery. The Miller lab has a long-standing expertise in vesicle formation and cargo selection, and largely uses yeast as a model system. We have in hand mutants that form the basis for this project, which will use a combination of genetics, biochemistry and structural biology to discover the mechanisms of selective and efficient ER export.

Funding Notes

Eligibility
Successful applicants receive full UKRI stipend (currently £18,622) also covering tuition fees, training, travel budget. We also offer enhanced support to individuals with primary care responsibilities or disabilities.
Applications in this round are open to Home students only i.e. candidates who qualify for 'Home' fee status, meeting UKRI terms/conditions.
To be classed as a Home student, candidates must meet the following criteria and the associated residency requirements:
• Be a UK National, or
• Have settled status, or
• Have pre-settled status, or
• Have indefinite leave to remain or enter
To Apply
Visit School of Life Sciences EASTBIO page for details. https://www.dundee.ac.uk/phds/funding/bbsrc-eastbio-doctoral-training-partnership-dtp-studentship

Where will I study?

University of Dundee

The University of Dundee brings together some of the best researchers in the world, developing ideas that positively impact the physical, social and psychological wellbeing of people and their communities, the economy, and the environment.