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EASTBIO Synthetic Proteins for Synthetic Biology

  • Full or part time
    Prof L Regan
  • Application Deadline
    Sunday, January 05, 2020
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

Second Supervisor:Chris Wood, University of Edinburgh

This project involves using protein design and selection methods to create novel protein-protein interactions that function in vivo. In prior work we have shown that by expressing designed proteins in vivo we can change key cellular functions.
This project involves extending this approach to develop novel ways to modulate intracellular pathways. This project will provide the student with interdisciplinary training, which can be fine-tuned to best match the interests of the student – structural, biochemical, molecular biological or computational. The project will also involve collaborations beyond the University of Edinburgh, and thus will provide many opportunities for professional development and for establishment of a personal global research network. This project is suitable for a student with an undergraduate degree in molecular biology, biochemistry, biophysics, cell biology, biotechnology, chemistry or related subjects.


Funding Notes

The “Visit Website” button will take you to our Online Application checklist. Complete each step and download the checklist which will provide a list of funding options and guide you through the application process. Follow the instructions on the EASTBIO website (you will be directed here from our application checklist), ensuring you upload an EASTBIO application form and transcripts to your application, and ticking the box to request references. Your referees should upload their references using the EASTBIO reference form, in time for the 5th January deadline so please give them plenty of time to do this by applying early.

References

A new method for post-translationally labeling proteins in live cells for fluorescence imaging and tracking. (2017) Hinrichsen M, Lenz M, Edwards JM, Miller OK, Mochrie SGJ, Swain PS, Schwarz-Linek U, Regan L. Protein Eng Des Sel. 30:771-780.

Design of Protein-Peptide Interaction Modules for Assembling Supramolecular Structures in Vivo and in Vitro. (2015) Speltz EB, Nathan A, Regan L. ACS Chem Biol.10:2108-15.

Designed proteins to modulate cellular networks (2010) Conrtajarena AL, Liu TY, Hochstrasser M, Regan L ACS Chem. Biol. 5:545-52

How good is research at University of Edinburgh in Biological Sciences?

FTE Category A staff submitted: 109.70

Research output data provided by the Research Excellence Framework (REF)

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