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Effect of microstructure in the mechanical response of cost-effective biomimetic constructs for rapid wound healing

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  • Full or part time
    Dr A Tsamis
    Prof J Pan
  • Application Deadline
    No more applications being accepted
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

A chronic wound is a wound that has failed to proceed through an orderly and timely process to produce anatomic and functional integrity or a wound that has proceeded through the repair process without establishing a sustained anatomic and functional result. Chronicity of a wound results in a burden on health care facilities and it is not uncommon for it to be financially and emotionally draining for the patient. According to the latest data from the Federal Ministry of Health Nigeria, 15 million inpatient surgical procedures were performed between 2015 and 2017 alone, followed closely by over 11.1 million outpatient surgeries.

The need for post-surgical wound care is sharply on the rise. Emergency wound care in an acute setting has major significance due to the presence of terrorism in Northern Nigeria due to Boko Haram insurgencies, as well as the unrest in southern Nigeria in the volatile areas where crude oil is drilled. The cost of this to the government is very low as the government does not fund healthcare, so there is a lot of needless death occurring due to unavailability of low-cost sustainable wound dressing materials to be used on chronic wounds, to avoid sepsis and disability due to amputations. Problems are closely linked to local social welfare and economic development. To solve these problems, a novel cost-effective wound dressing structure with the ability to speed up the healing process is needed.

In this collaborative interdisciplinary research project, Dr Tsamis, Prof Pan (University of Leicester), Dr Ilomuanya (University of Lagos) and Dr Wang (University of Manchester) aim at designing, fabricating, and evaluating a novel cost-effective wound dressing construct for rapid wound healing in resource-limited countries. The wound dressing construct, which will be designed and fabricated in Manchester using biomaterial prepared in Lagos based on plant extract, antimicrobial and growth factor (TAG), has the potential to facilitate wound healing in a resource-limited setting. The PhD project will be responsible for the computational and experimental evaluation of the mechanical response of the construct as a function of its microstructure, which will feed-back to improve the design of the construct.

Entry requirements

Applicants are required to hold/or expect to obtain a UK Bachelor Degree 2:1 or better in a relevant subject. The University of Leicester English language requirements apply where applicable.

How to apply

The online application and supporting documents are due by Monday 21st January 2019.

Any applications submitted after the deadline will not be accepted for the studentship scheme.

References should arrive no later than Monday 28th January 2019.

Applicants are advised to apply well in advance of the deadline, so that we can let you know if anything is missing from your application.

Required Materials
1. Online application form
2. Two academic references
3. Transcripts
4. Degree certificate/s (if awarded)
5. Curriculum Vitae
6. EPSRC Studentship Form
7. English language qualification

Applications which are not complete by the deadline will not be considered for the studentship scheme. It is the responsibility of the applicant to ensure the application form and documents are received by the relevant deadlines.

All applications must be submitted online, along with the supporting documents as per the instructions on the website. Please ensure that all email addresses, for yourself and your referees, are correct on the application form.

Project / Funding Enquiries

Application enquiries to [Email Address Removed]
Closing date for applications – 21st January 2019

Funding Notes

This research project is one of a number of projects in the College of Science and Engineering. It is in competition for funding with one or more of these projects. Usually the project that receives the best applicant will be awarded the funding.

Home/EU Applicants:
This project is eligible for a fully funded EPSRC studentship which includes:
• A full UK/EU fee waiver for 3.5 years
• An annual tax free stipend of £14,777 (2018/19)
• Research Training Support Grant (RTSG)

Studentships are available to UK/EU applicants who meet the EPSRC Residency Criteria; if you have been ordinarily resident in the UK for three years you will normally be entitled to apply for a full studentship.

If you are an EU student and do not meet the residency criteria, please contact [Email Address Removed] for more information on the funding options available.

International Applicants:
Unfortunately, there is no funding for international students on this project.

References

1. Jun I, Han HS, Edwards JR, Jeon H. “Electrospun fibrous scaffolds for tissue engineering: Viewpoints on architecture and fabrication.” International Journal of Molecular Sciences 19(3):745, 03/2018. doi: 10.3390/ijms19030745.
2. Liang D, Lu Z, Yang H, Gao J, Chen R. “Novel asymmetric wettable AgNPs/Chitosan wound dressing: in vitro and in vivo evaluation.” ACS Applied Materials & Interfaces 8(6):3958–3968, 02/2016. doi: 10.1021/acsami.5b11160.
3. Liu Y, Zhou S, Gao Y, Zhai Y. “Electrospun nanofibers as a wound dressing for treating diabetic foot ulcer.” Asian Journal of Pharmaceutical Sciences 2018. Article in Press. doi: 10.1016/j.ajps.2018.04.004.

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