About the Project
The human placenta is a critical life-support system for the developing fetus. The supply of oxygen and nutrients has to be well orchestrated within a complex fetal vascular network packed in irregular trees and surrounded by maternal blood flow, thus forming a disordered porous medium. Placental insufficiency could result in stillbirth or premature delivery, as well as in a higher risk of cardiovascular, metabolic and neurological disorders later in adult life with significant costs to society and healthcare. At the same time, the human placental arrangement is unique, having no close analogues in other species, so theoretical modelling is of particular value. However, the complexity of placenta prevents direct analysis and simulation at the organ level, and there is a lack of established modelling tools to manage the complexity.
This project will use a combination of analytical, statistical and computational approaches to establish how the placental transport of solutes and metabolites interacts with its structure. The models will be informed by unique three-dimensional X-ray tomography datasets acquired in Manchester, which span the spatial scales of 10 microns to 10 mm and reveal structural differences in normal and abnormal placentas. The clinical expertise in ultrasonic Doppler and magnetic resonance imaging will be utilised to validate the developed modelling tools.
The project will suit a student taking a Masters-level degree in applied mathematics, physics, bioengineering or a related area who has enthusiasm to apply their skills to a challenging biomedical application. Candidates are expected to hold (or be about to obtain) a minimum upper second class degree (or equivalent) in a related subject.
For international students we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences. For more information please visit www.internationalphd.manchester.ac.uk.
As an equal opportunities institution we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.
Informal enquiries may be made directly to the primary supervisor.
Nye GA, Ingram E, Johnstone ED, Jensen OE, Schneider H, Lewis RM, Chernyavsky IL & Brownbill P (2018) Human placental oxygenation in late gestation: experimental and theoretical approaches. J Physiol 596:5523-5534 (doi.org/10.1113/JP275633).
Ingram E, Morris D, Naish J, Myers J & Johnstone E (2017) MR Imaging Measurements of Altered Placental Oxygenation in Pregnancies Complicated by Fetal Growth Restriction. Radiology 285:953-960 (doi.org/10.1148/radiol.2017162385).
Junaid TO, Bradley RS, Lewis RM, Aplin JD & Johnstone ED (2017) Whole organ vascular casting and microCT examination of the human placental vascular tree reveals novel alterations associated with pregnancy disease. Sci. Rep. 7:4144 (doi.org/10.1038/s41598-017-04379-0).
Pearce P, Brownbill P, Janáček J, Jirkovská M, Kubínová L, Chernyavsky IL & Jensen OE (2016) Image-based modeling of blood flow and oxygen transfer in feto-placental capillaries. PLoS ONE 11:e0165369 (doi.org/10.1371/journal.pone.0165369).
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