Effects of estrogen on the activity of hypoxic neural networks

Project Overview

This project offers an exciting opportunity to understand how estrogen protects the brain from the effects of stroke. The lab has collected samples of neuronal activity from hypoxic brain slices. We are looking for a student with good programming skills to analyse the data and develop activity profiles that help us understand how estrogen affects neural network behaviour during oxygen deprivation. Depending on the outcome of this part of the study, we might perform further brain slice recordings, setting different experimental conditions. There are also opportunities to expand the project in different areas, as the methods of analysis developed by the student can be applied to further collections of neuronal data on neurotoxicity of insecticides.

Skill training and opportunities 

The project offers excellent opportunities for training and development. You will develop skills in programming and data analysis, delivering poster and powerpoint presentations in conferences, and writing scientific publications. Biological techniques that can be learned include PCR, immunohistochemistry, confocal microscopy, acute slice work using a novel technique for gathering viable slices, possible ELISA and electrophysiology. The student can also network with a vibrant group studying hormonal and neuronal function both in normal physiological states and disease.

Neural Models Group:

Our group uses models of the central nervous system to understand the brain and treat pathologies. We use stem cells, brain slices and primary cells to engineer neural networks that are examined under different conditions, and characterized using techniques such as PCR, electrophysiology and immunohistochemistry.

University of Reading:

The University of Reading, located west of London, England, provides world-class research education programs. The University’s main Whiteknights Campus is set in 130 hectares of beautiful parkland, a 30-minute train ride to central London and 40 minutes from London Heathrow airport. 

Our School of Biological Sciences conducts high-impact research, tackling current global challenges faced by society and the planet. Our research ranges from understanding and improving human health and combating disease, through to understanding evolutionary processes and uncovering new ways to protect the natural world. In 2020, we moved into a stunning new ~£60 million Health & Life Sciences building. This state-of-the-art facility is purpose-built for science research and teaching. It houses the Cole Museum of Zoology, a café and social spaces.

In the School of Biological Sciences, you will be joining a vibrant community of ~180 PhD students representing ~40 nationalities. Our students publish in high-impact journals, present at international conferences, and organise a range of exciting outreach and public engagement activities.

During your PhD at the University of Reading, you will expand your research knowledge and skills, receiving supervision in one-to-one and small group sessions. You will have access to cutting-edge technology and learn the latest research techniques. We also provide dedicated training in important transferable skills that will support your career aspirations. If English is not your first language, the University's excellent International Study and Language Institute will help you develop your academic English skills.

The University of Reading is a welcoming community for people of all faiths and cultures. We are committed to a healthy work-life balance and will work to ensure that you are supported personally and academically.

Eligibility:

·      Applicants should have a good bachelor’s degree (minimum of a UK Upper Second (2:1) or equivalent)/master’s degree in Biomedical Engineering or a strongly-related discipline.

·      International applicants will also need to meet the University’s English Language requirements. We offer pre-sessional English courses that can help with meeting these requirements. With a commitment to improving diversity in science and engineering, we encourage applications from underrepresented groups

The University of Reading is committed to a policy of equal opportunities and non-discriminatory treatment for all members of its community.

How to apply:

Submit an application for a PhD in Biomedical Engineering via our online application system.

Enquiries:

Dr. Evangelos Delivopoulos, email: e.delivopoulos@reading.ac.uk

Further information:

School of Biological Sciences PhD webpage