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Efficient simulation of the effect of mixing and flow condition on product crystal qualities in a continuous crystallizer using coupled CFD-PBE approach


School of Engineering

About the Project

The majority of the active pharmaceutical ingredients (APIs) used in the pharmaceutical industries are crystals of organic molecules. In these industries, crystallization is widely used as the principal method of separation and purification. As opposed to the traditionally used batch mode, the interest is continuous crystallization has increased significantly in recent years due to several benefits such as consistency of product quality and reduced manufacturing cost by improving asset utilization. While designing continuous crystallizer at the industrial scale, e.g., plug flow crystallizer (PFC), the effect of imperfect mixing and flow condition has to be considered since they can affect the product crystal qualities as well as plant operation significantly. For example, imperfect mixing can lead to local variation in supersaturation within the crystallizer that may results in excessive fine crystals. In order to take this variation into account while modelling continuous crystallization, this work aims at combining computational fluid dynamics (CFD) describing flow field with population balance equation (PBE) describing changes in the crystal phase. The solution of the governing equations for coupled CFD-PBE is computationally expensive. Thus, in most of the previous works that consider coupled CFD-PBE approach, the PBE is solved only in terms of moments of the crystal size distribution (CSD).

In this work, efficient solution techniques such as lattice Boltzmann method (LBM) will be used for solving the coupled CFD-PBE model equations, where the solution of the PBE in terms of CSD will be explored. LBM is the simulation approach that solves simplified governing equations at the mesoscopic level which is equivalent to solving the complicated nonlinear governing equations at the macroscopic level. These results will be very useful in designing industrial continuous crystallizer with particular application to pharmaceutical and chemical sectors.

Candidates should have (or expect to achieve) a UK honours degree at 2.1 or above (or equivalent) in Chemical Engineering or a similar discipline.

Knowledge or interest in process design, simulation and experience in computer programming (e.g., C/C++/FORTRAN) are highly expected

APPLICATION PROCEDURE:

• Apply for Degree of Doctor of Philosophy in Engineering
• State name of the lead supervisor as the Name of Proposed Supervisor
• State ‘Self-funded’ as Intended Source of Funding
• State the exact project title on the application form

When applying please ensure all required documents are attached:

• All degree certificates and transcripts (Undergraduate AND Postgraduate MSc-officially translated into English where necessary)
• Detailed CV

Informal inquiries can be made to Dr A Majumder (), with a copy of your curriculum vitae and cover letter. All general enquiries should be directed to the Postgraduate Research School ()



Funding Notes

This project is advertised in relation to the research areas of the discipline of Chemical Engineering. The successful applicant will be expected to provide the funding for Tuition fees, living expenses and maintenance along with Additional Research Costs of £1,500 in total. Details of the cost of study can be found by visiting View Website. THERE IS NO FUNDING ATTACHED TO THIS PROJECT.

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