About the Project
Experiment work involved:
1. Establish Eg7 tumor model in GFP-Egr2 knockin mice
2. Characterization of Egr2 positive TIL cells using EG7 tumor model with GFP-Egr2 knockin mice.
3. Examine the function of Egr2/3 positive or negative TIL T cells with proliferation assay, cytokine production and cytotoxic function to see the differences of sub-populations of TILs, providing the evidence why the novel immunotherapeutic strategy can be considered.
4. Define what are the role of Egr2 and 3 in regulation of tumour immune responses using Egr2/3 KO (Egr2/3 genes deleted in lymphocytes) and Egr2 Tg mice (Egr2 gene overexpressed in lymphocytes)
Recently the UK Government made available the Doctoral Student Loans of up to £25,000 for UK and EU students and there is some funding available through the Research Councils. Many of our international students benefit from funding provided by their governments or employers. Brunel alumni enjoy tuition fee discounts of 15%.
Miao, T., Symonds, A. L., Singh, R., Symonds, J. D., Ogbe, A., Omodho, B., Zhu, B., Li, S., Wang, P. Egr2 and 3 control adaptive immune responses by temporally uncoupling clonal expansion from T cell differentiation. Miao, T., Symonds, A. L., Singh, R., Symonds, J. D., Ogbe, A., Omodho, B., Zhu, B., Li, S., Wang, P. Egr2 and 3 control adaptive immune responses by temporally uncoupling clonal expansion from T cell differentiation. J Exp Med. 2017 Jun 5;214(6):1787-1808. doi: 10.1084/jem.20160553. Epub 2017 May 9.
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