About the Project
In this project, we plan to systematically investigate electrophysiological changes of the ion channels in human sperm cells, e.g. exposure to nanoparticles in the CatSper and Slo 3 channels in order to gain a deeper understanding of effects of these nanoparticles upon the function of the cells, for example, the main parameters of sperm function, including motility, viability, according to WHO guidelines and DNA fragmentation.
Our findings would provide useful information on the effect of nano versus bulk compounds on sperm and lymphocytes which might aid in therapeutic approaches. In addition, somatic lymphocyte cells after treatment with the same nanoparticles or bulk compound will be examined to determine differences in sensitivity between haploid and diploid cells.
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