£6,000 FindAPhD Scholarship | APPLICATIONS CLOSING SOON! £6,000 FindAPhD Scholarship | APPLICATIONS CLOSING SOON!

Elphinstone Scholarship - Novel interventions for treatment of diabetes and heart disease


   School of Medicine, Medical Sciences & Nutrition

This project is no longer listed on FindAPhD.com and may not be available.

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  Prof Mirela Delibegovic, Dr Nimesh Mody, Dr Dawn Thompson  No more applications being accepted  Funded PhD Project (Students Worldwide)

About the Project

Obesity is a major risk factor for development of insulin-resistance, diabetes and cardiovascular disease (CVD). CVD is the most prevalent cause of mortality among patients with diabetes, due to accelerated atherosclerosis. We previously demonstrated that inhibition of protein tyrosine phosphatase 1B (PTP1B) in vivo in mouse models of atherosclerosis improves insulin resistance, decreases circulating lipids and protects against atherosclerosis (1). We also demonstrated that inhibition of PTP1B specifically in the myeloid cells (macrophages) protects against atherosclerosis development in the absence of changes in body weight and adiposity (2). In this project we aim to mechanistically investigate the effects of PTP1B inhibition on signalling networks thought to be key in pathogenesis of atherosclerosis and diabetes as well as assess the translational potential of these findings. The student will gain excellent training within the basic and clinical sciences and as an integral member of the Aberdeen Cardiovascular and Diabetes Centre; with training in advanced statistics, biochemical and molecular biology techniques, in vivo metabolic testing and imaging and cell culture of primary murine and human cells. 

Informal enquiries are encouraged, please contact the lead supervisor Prof. Mirela Delibegovic ( [Email Address Removed]) for further information.

Essential background of student:

Applicants should hold a 1st Class UK Honours degree (or international equivalent) in a relevant subject. Those with a 2:1 UK Honours degree (or international equivalent) may be considered, provided they have (or are expected to achieve) a Distinction or Commendation at Master’s level.

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This project will be based within the Institute of Medical Sciences (IMS), part of the School of Medicine, Medical Sciences and Nutrition, at the University of Aberdeen. The IMS is located on the Foresterhill Health Campus, one of the largest clinical complexes in Europe, which also includes the Institute of Applied Health Sciences, the Rowett Institute, and a large teaching hospital.

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APPLICATION PROCEDURE:

Please note: The funding for this project covers tuition fees and research costs only, no stipend or living costs are provided.

  • Formal applications can be completed online: https://www.abdn.ac.uk/pgap/login.php
  • You should apply for Medical Sciences (PhD) to ensure your application is passed to the correct team.
  • Please clearly note the name of the lead supervisor and project title on the application form. If you do not mention the project title and the supervisor on your application it will not be considered for the studentship.
  • Please include a personal statement, an up-to-date copy of your academic CV, and relevant educational certificates and transcripts (Undergraduate and postgraduate (if applicable)).
  • Please note: you DO NOT need to provide a research proposal with this application
  • CV's submitted directly through a FindAPhD enquiry WILL NOT be considered.
  • General application enquiries can be made to [Email Address Removed] 

Funding Notes

This 36 Month project is funded by a prestigious University of Aberdeen Elphinstone Scholarship. This opportunity is open to UK and International students and includes funding to cover tuition fees and research costs only. No stipend or living costs are provided.
Funding for international students does not cover visa costs (either for yourself or for accompanying family members), immigration health surcharge or any other additional costs associated with relocation to the UK.
The expected start date is February 2023.

References

(1) Pharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR-/- mouse model of atherosclerosis.
Thompson D, Morrice N, Grant L, Le Sommer S, Lees EK, Mody N, Wilson HM, Delibegovic M. Clin Sci (Lond). 2017 Sep 28;131(20):2489-2501. doi: 10.1042/CS20171066. Print 2017 Oct 1
(2) Myeloid protein tyrosine phosphatase 1B (PTP1B) deficiency protects against atherosclerotic plaque formation in the ApoE-/- mouse model of atherosclerosis with alterations in IL10/AMPKα pathway.
Thompson D, Morrice N, Grant L, Le Sommer S, Ziegler K, Whitfield P, Mody N, Wilson HM, Delibegović M. Mol Metab. 2017 Jun 13;6(8):845-853. doi: 10.1016/j.molmet.2017.06.003. eCollection 2017 Aug.
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