About the Project
The objectives of the project are to: (i) develop novel photo-crosslinkers, and use these to (ii) map the CypD interactome. State-of-the-art techniques to be used include chemical tag-transfer photo-crosslinking, proteins bearing unnatural amino acids which are introduced using recombinant methods; mass spectrometry proteomics, very high field nuclear magnetic resonance spectroscopy and confocal imaging. This project is designed to closely integrate Life Sciences with Chemistry. The student will exploit preliminary Systems Biology (Multiomics) data and develop interdisciplinary skills in Biochemistry, Biophysics and Chemical Biology to address the project objectives.
The project will suit students with a strong organic chemistry, chemical biology or biochemistry background who are interested in applying their skills to address challenging biological problems that will lead to the elucidation of basic mechanisms and enable drug discovery. This project is part of a larger research programme where clinicians, chemists and biochemists are already working together to develop new inhibitors of Cyclophilin D.
Assistance will be given to those who are applying to international funding schemes.
The successful applicant will be expected to provide the funding for tuition fees and living expenses as well as research costs of £7000 per year.
Details of costs can be found on the University website:
2. Horne JE, Walko M, Calabrese AN, Levenstein MA, Brockwell DJ, Kapur N, Wilson AJ, Radford SE (2018) Rapid Mapping of Protein Interactions Using Tag-Transfer Photocrosslinkers, Angew. Chemie. Int. Ed., 57:16688–1669
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