About the Project
The main goal of the project is to decipher how the cellular metabolic state modulates these mitochondria-organelle contact sites and their interplay with the control of mitochondrial morphology, and vice-et-versa. To address these fundamental questions, the Ph.D candidate will employ classical biochemical and molecular techniques coupled with advanced proteomic analysis. The student will also use the state-of-the-art microscopy analysis, including confocal, super-resolution and electron microscopy, as well as quantitative high-resolution live-cell imaging to finely decipher the molecular architecture and mechanisms regulating these events and to elucidate how mitochondrial membranes remodeling controls cell fate decisions.
General keywords: Molecular and Cell biology, Mitochondria, Inter-organelle contacts.
More specific keywords: Mitochondrial dynamics, Fission and Fusion, Cell fate decision, TGN vesicles.
Related subjects: Cell Biology, Molecular Biology, Biochemistry, Microscopy.
Recruitment will close early if this studentship is awarded before the end of June.
Tilokani L, Nagashima S, Paupe V, Prudent J. Mitochondrial dynamics: overview of molecular mechanisms. Essays Biochem. 2018 Jul 20;62(3):341-360. doi: 10.1042/EBC20170104.
Morita M, Prudent J, Basu K, Goyon V, Katsumura S, Hulea L, Pearl D, Siddiqui N, Strack S, McGuirk S, St-Pierre J, Larsson O, Topisirovic I, Vali H, McBride HM, Bergeron JJ, Sonenberg N. mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1. Mol Cell. 2017 Sep 21;67(6):922-935.e5. doi: 10.1016/j.molcel.2017.08.013
Prudent J, McBride HM. The mitochondria-endoplasmic reticulum contact sites: a signalling platform for cell death. Curr Opin Cell Biol. 2017 Aug;47:52-63. doi: 10.1016/j.ceb.2017.03.007.
Sugiura A, Mattie S, Prudent J, McBride HM. Newly born peroxisomes are a hybrid of mitochondrial and ER-derived pre-peroxisomes. Nature. 2017 Feb 9;542(7640):251-254. doi: 10.1038/nature21375.
Prudent J, Zunino R, Sugiura A, Mattie S, Shore GC, McBride HM. MAPL SUMOylation of Drp1 Stabilizes an ER/Mitochondrial Platform Required for Cell Death. Mol Cell. 2015 Sep 17;59(6):941-55. doi: 10.1016/j.molcel.2015.08.001.
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