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Elucidating the mechanisms of pathology in neurodevelopmental white matter diseases


   Department of Infection, Immunity and Cardiovascular Disease


About the Project

Our research interests are to dissect the mechanism of auto-inflammatory neurological disorders using zebrafish as an animal model.

Leukodystrophies are devastating rare monogenic neurological diseases with loss of white matter.  Many leukodystrophies have been described (over 200) due to advances in sequencing capabilities to identify mutations in new genes. However, for most of those diseases, there is limited research and models available and there is no treatment available.

I have previously published the first zebrafish model to study leukodystrophies (Haud et al, PNAS, 2011) and used this model to identify cellular drivers (Hamilton et al, Glia 2020). To expand the number of models available and boost research on leukodystrophies, I co-led the creation of LEUKOLABS, a new network to unite leukodystrophy researchers in the UK. Through this network, multiple research models will be combined to study new leukodystrophy identified and the student will be working towards elucidating the mechanism of pathology. This will advance our understanding of these rare diseases and contribute to the development of therapies.

Funding:

for self-funded applicants

Entry Requirements:

Candidates must have a first or upper second-class honors degree and some research experience is desirable.

Enquiries:

Interested candidates should in the first instance contact Dr Noémie Hamilton at

https://www.sheffield.ac.uk/iicd/profiles/hamilton

How to apply:

Please complete a University Postgraduate Research Application form available here: www.shef.ac.uk/postgraduate/research/apply

Please clearly state the prospective main supervisor in the respective box and select 'Infection, Immunity & Cardiovascular Disease' as the department.


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