Please note, this is a self-funded project and does not include tuition fees or stipend; the studentship is available to Students Worldwide. Fee bands are available at View Website . A relevant fee band will be discussed at interview based on project running costs.
1) Effect of TDP2 on the level of TOP2-DNA complexes and SUMOylated TOP2-DNA complexes. Lee KC, Swan R, Sondka Z, Padget K, Cowell I & Austin CA. (2018) Int J Mol Sci. 2018 Jul 14;19(7). pii: E2056.
2) Genome wide ChIP-seq analysis of human TOP2B occupancy in MCF7 breast cancer epithelial cells. Manville C, Smith K, Sondka Z, Rance H, Cockell S, Cowell I, Lee K, Morris N, Padget K, Jackson G, Austin CA. (2015) Biology Open 4(11): 1436-1447.
3) MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA. Lee KC, Padget K, Curtis H, Cowell IG, Moiani D, Sondka Z, Morris NJ, Jackson GH, Cockell SJ, Tainer JA, Austin CA. (2012) Biol Open. Sep 15;1 (9):863-73.
4) Model for MLL translocations in therapy-related leukemia involving topoisomerase IIβ-mediated DNA strand breaks and gene proximity. Cowell IG, Sondka Z, Smith K, Lee KC, Manville CM, Sidorczuk-Lesthuruge M, Rance HA, Padget K, Jackson GH, Adachi N, Austin CA. (2012) Proc Natl Acad Sci U S A. Jun 5;109 (23):8989-94.
5) Histone deacetylase inhibition redistributes topoisomerase IIβ from heterochromatin to euchromatin. Cowell IG, Papageorgiou N, Padget K, Watters GP, Austin CA. (2011) Nucleus. Jan-Feb;2(1):61-71.