Bioactive plant metabolites are an essential source of chemical scaffolds for the development of new medicines. However, their complex chemical structures and intricate stereochemistry often render their chemical synthesis unfeasible. Recent progress in sequencing and metabolomics technologies has opened a new avenue towards heterologous production of plant metabolites using their native biosynthetic enzymes. In this project we will apply these cutting-edge technologies to elucidate the biosynthetic pathways of unique terpenoid molecules in their native plant hosts and engineer them into microbial production systems. Terpenoids represent the largest and the most diverse—but also the least characterized—class of plant specialized metabolites with numerous medical or industrial applications. This project will mainly use biochemistry and molecular biology approaches, with some application of novel computational tools.
How to apply
To apply for a PhD study at IOCB Prague, you must hold a Master’s degree (MSc) or the equivalent of the MSc in similar field (four or five year undergraduate degree). The application can be submitted before obtaining the Master’s degree, however, the applicant should obtain the degree within five months after the application deadline.
For more information visit our website “Call for PhD applications 2020”: https://www.uochb.cz/en/phd-program
If you decided to apply, please do so online via our application form: https://www.uochb.cz/en/call-for-phd-applications
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