The project is suited to a student with an undergraduate degree or Master’s degree in Life Sciences (Biology, Genetics, Biochemistry, Biomedical Sciences, Cell Biology) or Medicine with an interest in extracellular matrix and cellular trafficking.
PLEASE NOTE: there is NO funding attached to this project. Details of costs can be found on the University website. The successful applicant will be expected to provide the funding for tuition fees and living expenses plus approximate research costs (bench fees) of approximately £10,000 per year.
1. Yamamoto K, Troeberg L, Scilabra SD, Pelosi M, Murphy CL, Strickland DK and Nagase H. LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage. (2013) FASEB J, 27, 511-521.
2. Yamamoto K, Owen K, Parker AE, Scilabra SD, Dudhia J, Strickland DK, Troeberg L and Nagase H. Low-density lipoprotein receptor-related protein 1 (LRP1)-mediated endocytic clearance of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-4: Functional differences of non-catalytic domains of ADAMTS-4 and ADAMTS-5 in LRP1 binding. (2014) J Biol Chem, 289, 6462-6474.
3. Yamamoto K, Okano H, Miyagawa W, Visse R, Shitomi Y, Santamaria S, Strickland DK, Hirohata S and Nagase H. MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1. (2016) Matrix Biol, 56, 57-73.
4. Yamamoto K, Santamaria S, Botkjaer K, Dudhia J, Troeberg L, Itoh Y, Murphy G and Nagase H. Inhibition of shedding of low-density lipoprotein receptor-related protein 1 reverses cartilage matrix degradation in osteoarthritis. (2017) Arthritis Rheumatol, 69(6), 1246-1256.
FTE Category A staff submitted: 143.50
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