Looking to list your PhD opportunities? Log in here.
About the Project
Our hypothesis is that ESCRTs have a role to play in the acquisition of drug resistance in colon cancer, and this project will investigate this hypothesis. The project will develop a series of cell lines expressing specific ESCRT family members which have been modified using gene knock-in/-out techniques in the parent line. The acquisition of drug resistance over time in the knockout cell line compared with the wild type cell line will then be assessed. Also important would be to see if alteration in ESCRT machinery expression effects sensitivity to a range of drugs and not just the drug used previously, suggesting involvement of the ESCRTs in a multiple drug resistance phenotype.
The project will also look at the expression of ESCRTs in clinical material from treated and naïve patients to see if the experimental expression patterns are valid in a clinical setting.
In establishing if the cell line model can be utilised as an in vivo experimental model for evaluating therapeutic intervention to modulate acquired drug resistance, mouse xenograft studies will take place in the last year of the project looking at treatment efficacy and effects on protein expression in wild type and altered expression cell lines.
If the hypothesis is proved in this project, then we will look to disseminate the findings in peer-reviewed scientific journals and through attendance at national and international conferences.
Funding Notes
Email Now
Why not add a message here
The information you submit to University of Bradford will only be used by them or their data partners to deal with your enquiry, according to their privacy notice. For more information on how we use and store your data, please read our privacy statement.

Search suggestions
Based on your current searches we recommend the following search filters.
Check out our other PhDs in Bradford, United Kingdom
Check out our other PhDs in United Kingdom
Start a New search with our database of over 4,000 PhDs

PhD suggestions
Based on your current search criteria we thought you might be interested in these.
Nanotechnologies for cancer: developing new polymer-drug conjugates for the treatment of a range of cancers
University of Reading
Cancer: Epigenetic therapy using microbubble-mediated drug delivery for colorectal cancer
University of Leeds
Investigating the role of the biofilm in waste water treatment plants as a reservoir for antimicrobial resistance
Glasgow Caledonian University