EngDs studentship in Development and optimisation of novel bioprinting process for scalable production of tissue models
The Engineering Doctorates (EngDs) studentship is based within Dr Deepak Kalaskar’s Bioengineering group, part of the Institute of Orthopaedics and Musculoskeletal Sciences and multidisciplinary research facility, with a focus on 3D bioprinting for disease modelling and Tissue engineering applications. The studentship is supported by UCL Centre for Doctoral Training in Bioprocess Engineering Leadership and is in collaboration with an innovative SME, Manchester Biogel Ltd.
Studentship Description More than 5 million people in the UK are affected by Osteoarthritis (OA) every year, placing a multi-billion-pound burden on the local economy and the NHS. Despite more than 50 years of research, no effective drug is commercially avaialble for OA. In vitro models are deemed an ethical alternative of the animal models – the most common model currently – in drug development but only simple model, typically with single tissue component, have been proposed due to their inherent scaffold related limitations, i.e. poor cell viability and instable cell phenotype. There is therefore an urgent unmet need for new technological platforms that enable reproducible and integrative human relevant OA in vitro models.
This project will address this urgent need by developing, testing and optimising such a technological platform by combining hydrogel development and 3D printing to produce standardisable and translational human relevant OA joint models that will be demonstrated for use within high throughput biomanufacturing.
This project will be based within the UCL Division of Surgery and Interventional Science, in collaboration with the SME Manchester BIOGEL.
Person Specification Essentials: Applications are sought from candidates with a minimum of an upper-second-class Honours degree or an MSc in biological science, bioengineering, materials science, biomaterials science, or a related subject. Good analytical, experimental, project management and communication skills are required. Candidate should be fluent in written and spoken English. Candidates with experience in mammalian cell biology or use of biomaterials are encouraged to apply.
This research is joint project between industry based in Manchester and UCL (London). Candidate must be willing to travel frequently and spend time at industry to fulfil the project requirements.
Desirable: Previous cell culture, immunostaining, histology experience, 3D printing and experience of working with CAD software will be valuable. Previous experience of publication will be seen positively.
Eligibility Due to funding restrictions, this studentship is open to UK/EU candidates only.
To make an application, please email your CV and a covering letter to: Dr Deepak Kalaskar ([Email Address Removed]) explaining your interests, and research experience (including examples of previous project work related to propose studentship).
The studentship covers the full cost of UK/EU tuition fees, plus a tax free stipend of £17,009 p.a. for four years.