Engineered Nanomaterials for Selective Targeting of Cancer-Associated Sialoglycans

Every cell type in nature is coated with a complex mixture of type-specific sugars called glycans (also known as carbohydrates). Glycans are attached to cell surface proteins and lipids and carry unique information in biological systems that make them important biomarker candidates for a wide range of diseases. Importantly, abnormal changes in the type and density of cell surface glycans is a well-established characteristic of nearly all cancer cells from different kinds of tissue origins.

In this regard, one of the most remarkable alterations in cancer cells in comparison to the normal healthy counterpart, is that they cover their surface with a dense layer of sialic acid–carrying glycans (sialoglycans). Selective recognition of sialoglycans therefore provides a unique opportunity for glycan-based therapeutics and diagnostics.

The goal of this PhD project is to produce lipid-based nanoparticles for sialoglycan targeting using concepts and tools from lipid membrane biophysics and molecular imprinting. The research will involve close collaboration with biologists and will make use of the unique combination of experimental equipment that is available in the School of Chemistry and Chemical Engineering, as well as advanced imaging facilities at the Faculty of Medicine, Health, and Life Sciences.

Eligibility

·       Candidates must have, or expect to obtain, a 2:1 or first-class degree in Chemistry or closely related discipline

·       Due to funding restrictions, the position is only available for UK-resident candidates (UK and ROI nationals, or EU nationals that have obtained settled status in the UK)

·       Full eligibility information can be viewed via: https://www.nidirect.gov.uk/articles/department-economy-studentships

·       Candidates must be available to start the post by October 2022

How to Apply

Applications must be submitted online via the University's Postgraduate Application Portal Login - Applications Portal (qub.ac.uk).

For more information please contact: Dr Seyed Tabaei ([Email Address Removed]).