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Engineering E. coli as a cell factory for biotechnology

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

The model bacterium Escherichia coli is metabolically versatile with ability to adapt to ever changing environmental conditions by reprogramming gene expression. These responses are essential for competitiveness in nature and for productivity when E. coli is used as a cell factory in biotechnological processes. One of our core interests is in understanding how E. coli responds to stresses related to oxygen availability and reactive oxygen species. Previous work has established mechanisms of oxygen sensing and how this is transduced into altered patterns of gene expression via interactions between transcription factors and RNA polymerase. We are interested in developing this research to better understand the stress responses of E. coli operating in a biotechnology setting and use this information to engineer more productive cell factories. To achieve this goal we will apply a range of ‘omic techniques and molecular genetics (synthetic biology) followed by phenotypic analyses to identify strains with desirable characterisitics.

Science Graduate School

As a PhD student in one of the science departments at the University of Sheffield, you’ll be part of the Science Graduate School – a community of postgraduate researchers working across biology, chemistry, physics, mathematics and psychology. You’ll get access to training opportunities designed to support your career development by helping you gain professional skills that are essential in all areas of science. You’ll be able to learn how to recognise good research and research behaviour, improve your communication abilities and experience technologies that are used in academia, industry and many related careers. Visit to learn more.

Funding Notes

Entry requirements
First class or upper second 2(i) in a relevant subject. To formally apply for a PhD position, you must complete the University's application form using the following link: View Website

*All applicants should ensure that both references are uploaded onto their application as a decision will be unable to be made without this information*.

Related Subjects

How good is research at University of Sheffield in Biological Sciences?

FTE Category A staff submitted: 44.90

Research output data provided by the Research Excellence Framework (REF)

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