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Engineering non-model yeasts with biotechnological potential

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

The biochemical industry is moving away from a reliance on fossil fuels to produce fine chemicals and is exploring the use of microbes as cell factories. The large variety of physiological and metabolic characterisitics of different yeast species make this group of organisms especially interesting for production of so called ‘green chemicals’. However, the tools to genetically engineer these organsims are limiting or non-existent. We will be developing genome editing tools to engineer a panel of yeasts species with promising characteristics and will 1) introduce a novel biosynthetic pathway into these species and 2) we will design small scale assays to compare growth on different ‘wastes’ as feedstocks and 3) determine product yield. With this approach we will be constructing a pipeline to rapidly identify combinations of yeast species, feedstock usage and yield in the production of a particular fine chemical. This project will be a close collaboration between the Hettema Lab and the Gilmour Lab.

Science Graduate School

As a PhD student in one of the science departments at the University of Sheffield, you’ll be part of the Science Graduate School – a community of postgraduate researchers working across biology, chemistry, physics, mathematics and psychology. You’ll get access to training opportunities designed to support your career development by helping you gain professional skills that are essential in all areas of science. You’ll be able to learn how to recognise good research and research behaviour, improve your communication abilities and experience technologies that are used in academia, industry and many related careers. Visit to learn more.

Funding Notes

My lab welcomes applications from self-funded prospective home and international PhD students interested in molecular cell biology projects or biotechnology
View Website

To formally apply for a PhD position, you must complete the University's application form using the following link: View Website

*All applicants should ensure that both references are uploaded onto their application as a decision will be unable to be made without this information*.

How good is research at University of Sheffield in Biological Sciences?

FTE Category A staff submitted: 44.90

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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