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Engineering Oxygenase Enzymes


Project Description

A Ph.D. position is available in the groups of Professor Gideon Grogan and Dr Jared Cartwright in the Departments of Chemistry and Biology at the University of York. The position is open to applicants from the U.K. and the E.U. This project will focus on the evolution of new oxygenase enzymes for the preparative biotransformation of pharmaceutical intermediates. The work will involve a range of techniques in chemistry, molecular biology, biochemistry and structural biology.

The project is funded by a studentship from the industrial affiliates of the Centre of Excellence for Biocatalysis (CoEBio3; http://www.coebio3.manchester.ac.uk/). The successful applicant will have, or should expect to obtain, a first-class degree in biochemistry, molecular biology or biotechnology, and should also have a good background knowledge of organic chemistry. Experience with cloning and expression in yeast systems would be an advantage. The position will be funded for three-and-a-half years, and will involve close collaboration with the industrial affiliates of CoEBio3, including reports and presentations at six-monthly meetings.

All research students follow our innovative Doctoral Training in Chemistry (iDTC): cohort-based training to support the development of scientific, transferable and employability skills. All research students take the core training package which provides both a grounding in the skills required for their research, and transferable skills to enhance employability opportunities following graduation. Core training is progressive and takes place at appropriate points throughout a student’s higher degree programme, with the majority of training taking place in Year 1. In conjunction with the Core training, students, in consultation with their supervisor(s), select training related to the area of their research.

Students also receive training within their research group.

The Department of Chemistry holds an Athena SWAN Gold Award and is committed to supporting equality and diversity for all staff and students. The Department strives to provide a working environment which allows all staff and students to contribute fully, to flourish, and to excel: https://www.york.ac.uk/chemistry/ed/.

This PhD will formally start on 1 October 2019. Induction activities will start on 30 September.

Please send informal enquiries to or

Funding Notes

The studentship is fully funded for 3.5 years by the Centre of Excellence for Biocatalysis (CoEBio3) and covers: (i) a tax-free annual stipend at the standard Research Council rate (£15,009 for 2019-20), (ii) tuition fees at the UK/EU rate, (iii) funding for consumables.

References

Candidate selection process:

• Candidates should submit an online application for a PhD in Chemistry by 10 May 2019
• Supervisors may contact their preferred candidates either by email, telephone, web-chat or in person
• Supervisors will select their preferred candidate for approval from those that meet the University’s entry requirements
• Candidates will be notified of the outcome by email

How good is research at University of York in Chemistry?

FTE Category A staff submitted: 47.06

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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