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  Engineering Protein Nanocompartments for Biotechnological Applications


   Department of Chemical & Biological Engineering

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  Dr Kang Lan Tee  Applications accepted all year round  Self-Funded PhD Students Only

About the Project

Protein nanocompartments have board applications as catalytic nanoreactors and as carriers for therapeutics delivery. They are self-assembled protein-based supramolecules that have spherical and hollow architectures. As recombinant proteins, they are amendable to both genetic and chemical modification and have manufacturing scalability. The spherical hollow structures of protein cage nanoparticles provide an interior space to carry protein cargo and an exterior surface for functionalization. This creates a modular design space for tailoring the nanoparticle to suit diverse applications.

In this project, the candidate will explore different design approaches to engineer protein nanocompartments into catalytic nanoreactors and carriers for target therapeutics delivery. This can include top-down modification of natural protein nanocontainers, bottom-up design of novel protein nanoparticles, and directed evolution of nanocompartment scaffolds. 

During the project, the candidate will receive training at the interface of engineering and biological sciences. The candidate will gain expertise in the areas of industrial biotechnology and synthetic biology. The candidate will also benefit from the resources, supports, and training from the Engineering Graduate School, the Faculty and the Departmental Employability Teams, allowing the candidate to develop into a future leader in biomanufacturing.

Please contact Dr. Kang Lan Tee ([Email Address Removed]) for information or informal discussion about this opportunity.

Please see this link for information on how to apply: https://www.sheffield.ac.uk/cbe/postgraduate/phd/how-apply. Please include the name of your proposed supervisor and the title of the PhD project within your application.

Applicants must have achieved or expect to achieve a 1st class or 2:1 honours degree or equivalent in a related discipline in Chemical/Biochemical/Environmental Engineering, Biotechnology, Bioscience/Microbiology/Molecular Biology, Chemistry or related disciplines. If English is not your first language then you must have an International English Language Testing System (IELTS) average of 6.5 or above with at least 6.0 in each component, or equivalent. Please see this link for further information: https://www.sheffield.ac.uk/postgraduate/phd/apply/english-language.

Biological Sciences (4) Chemistry (6) Engineering (12)

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 About the Project