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Engineering Virus-Like Particles (VLPS) for the Next-Generation Vaccines


   Department of Chemical & Biological Engineering


About the Project

Virus-like particles (VLPs) are molecules that mimic viruses and will trigger immune response when introduced into body. As they do not contain any viral genetic material, they are not infectious. They typically consists of one or more structural proteins that can be arranged in multiple layers. They are therefore a highly effective means of creating safe, efficacious, and profitable vaccines against diseases such as human papillomavirus (HPV), hepatitis B, malaria, and many more.

In this project, the candidate will apply state-of-the-art protein engineering approach engineer self-assembling proteins to mimic natural virus structures. The candidate will also use advanced light scattering techniques to characterize native and engineered VLPs.

During the project, the candidate will receive training at the interface of engineering and biological sciences. The candidate will gain expertise in the areas of protein science, particle science, and analytical science. The candidate will also benefit from the resources, supports, and training from the Engineering Graduate School, the Faculty and the Departmental Employability Teams, allowing the candidate to develop themselves into a future leader in bioeconomy.

For more information about the research conducted in Wong and Tee research groups, please visit:

Wong Research Group: https://www.wongbiomanufacturing.com/.

Tee Research Group: https://sites.google.com/sheffield.ac.uk/kanglanteelab/.

Please see this link for information on how to apply: https://www.sheffield.ac.uk/cbe/postgraduate/phd/how-apply. Please include the name of your proposed supervisor and the title of the PhD project within your application.

Applicants must have achieved or expect to achieve a 1st class or 2:1 honours degree or equivalent in a related discipline in Chemical/Biochemical/Environmental Engineering, Bioscience/Microbiology/Molecular Biology or Chemistry. If English is not your first language then you must have an International English Language Testing System (IELTS) average of 6.5 or above with at least 6.0 in each component, or equivalent. Please see this link for further information: https://www.sheffield.ac.uk/postgraduate/phd/apply/english-language.


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