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EngSci-Bio-129: Characterization of the 3-D structure of the airways in health and disease using micro-CT

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  • Full or part time
    Dr J A Warner
    Dr P Schneider
  • Application Deadline
    No more applications being accepted
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

This project will characterize the 3-D organisation of the airways and accompanying vasculature in health and disease. Using conventional wax-embedded lung biopsies imaged with a micro-computed tomography (µCT) scanner from Nikon Metrology UK at a resolution of better than 10 microns normal and diseased lung microstructures, such as airways and blood vessels can be identified and characterized in 3-D. The student will work in the Faculties of Medicine and Engineering at the University of Southampton, collaborating with Nikon Metrology UK to develop robust techniques for the analysis and identification of key features of the airways and their accompanying vasculature. Changes in these will be related to disease pathology in conditions such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF). The project brings together several established collaborations into a multi-disciplinary consortium including engineering scientists, medical scientists, pathologists and medical informatics.

This MRC funded Industrial CASE PhD studentship (stipend in the region of £16,000 pa) offers a unique interdisciplinary life sciences programme of work based at a world class research centre collaborating with Nikon Metrology UK with shared support from the Faculties of Medicine and Engineering and the Environment at the University of Southampton. The PhD candidate will benefit from the exceptional opportunity to gain expertise in cutting-edge bioimaging technologies and computational modelling methods applied to relevant health questions.

Please contact: Dr Jane Warner ([Email Address Removed]) or Dr Philipp Schneider ([Email Address Removed])

Person Specification:

The successful candidate is likely to have the following qualifications:
The candidate will have, or expect to have, a first or upper second class honours degree (or equivalent) with an interest in BioMedicine. Experience of biomedical imaging or computational modelling approaches would be advantageous but not essential.
Funding information:

Administrative contact and how to apply:

Please complete the University’s online application form, which you can find at

You should enter Jane Warner as your proposed supervisor. To support your application provide an academic CV (including contact details of two referees), official academic transcripts and a personal statement (outlining your suitability for the studentship, what you hope to achieve from the PhD and your research experience to date).

Informal enquiries relating to the project or candidate suitability should be directed to Jane Warner ([Email Address Removed]) or Dr Philipp Schneider ([Email Address Removed])

Visit our Postgraduate Research Opportunities Afternoon to find out more about Postgraduate Research study within the Faculty of Engineering and the Environment:

How good is research at University of Southampton in General Engineering?

FTE Category A staff submitted: 192.23

Research output data provided by the Research Excellence Framework (REF)

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