Postgrad LIVE! Study Fairs

Bristol

Coventry University Featured PhD Programmes
FindA University Ltd Featured PhD Programmes
University of Huddersfield Featured PhD Programmes
University of West London Featured PhD Programmes
University of Bristol Featured PhD Programmes

Enhancing early stage drug discovery using a transformative approach to crystal structure determination

  • Full or part time

    Dr K Shankland
  • Application Deadline
    Monday, March 04, 2019
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

Crystal structures provide knowledge of both the 3-dimensional shapes of drug development compounds and how to improve a compound’s physical properties (e.g. solubility). This knowledge is useful at all stages of a drug development programme, from hit identification through to lead optimisation and beyond into formulation. In many cases, it is not possible to grow large enough single crystals of the compounds, preventing the use of single-crystal X-ray studies. In such cases, crystalline powders can still be obtained and powder X-ray diffraction can be used to allow crystal structure determination from powder data. The problem often encountered here, however, is the requirement of around 25-50 mg of material. Such amounts are simply not available until the choice of lead compound for the programme has already been made. Therefore, crystal structures obtained by SDPD come too late in the drug development process to influence crucial early decision-making.
The aim of this PhD project is to develop new methodologies for crystal structure determination from powder diffraction data using very small amounts of material, suitable for adoption by industry at the very beginning of a drug discovery programme. The work is ambitious, involving crystallisation, crystallography, data analysis and (potentially) software development. The successful candidate, based at the University of Reading (but also spending time at C4X Discovery in Manchester), will emerge with a set of skills highly relevant to academia and industry

Funding Notes

Applicants should hold, or expect to gain, a minimum of a 2:1 Bachelor Degree or equivalent in Chemistry, Chemical Engineering, Pharmacy or Pharmaceutical Sciences, or another directly relevant discipline.

Due to restrictions on the funding, this studentship is open to UK/EU applicants only. Please note: EU applicants only qualify for a stipend if they have been resident in the UK for the 3 years leading up to the start of the PhD.

How good is research at University of Reading in Allied Health Professions, Dentistry, Nursing and Pharmacy?

FTE Category A staff submitted: 23.20

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

Email Now

Insert previous message below for editing? 
You haven’t included a message. Providing a specific message means universities will take your enquiry more seriously and helps them provide the information you need.
Why not add a message here
* required field
Send a copy to me for my own records.

Your enquiry has been emailed successfully





FindAPhD. Copyright 2005-2019
All rights reserved.