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Enhancing Macrophage-Biofilm Interaction using Non-Thermal Plasma


Project Description

The ability to generate plasmas (quasi-neutral, wholly or partially ionised gases) at ambient or tissue tolerable temperatures has given rise to the nascent field of plasma medicine. Cold plasmas have rapidly evolved as a technology for biological applications such as microbial decontamination and wound healing, owing to the chemical and bioactive radicals generated reactive oxygen (ROS) and nitrogen species (RNS), known collectively as RONS. This technology is increasingly proposed for applications in human medicine and recently we have demonstrated the efficacy of cold plasma for biofilm eradication and control across a range of human pathogens. Recent work has also described the potential of cold plasma to activate cells of the immune system for enhanced clearance of infection.
This PhD programme will elucidate the mechanisms of immune cell activation and aims to understand the potential for cold plasma to enhance the clearance of biofilms by cells of the immune system, using a range of advanced techniques in plasma physics, biofilm- and molecular microbiology. This project forms part of a major collaboration with research groups in the USA and Republic of Ireland, with opportunities to conduct research in each of the centres.

Funding Notes

Applicants should have a 1st or 2.1 honours degree (or equivalent) in a relevant subject. Relevant subjects include Pharmacy, Molecular Biology, Pharmaceutical Sciences, Biochemistry, Biological/Biomedical Sciences, Chemistry, Engineering, or a closely related discipline. Students who have a 2.2 honours degree and a Master’s degree may also be considered, but the School reserves the right to shortlist for interview only those applicants who have demonstrated high academic attainment to date

How good is research at Queen’s University Belfast in Allied Health Professions, Dentistry, Nursing and Pharmacy?
Pharmacy

FTE Category A staff submitted: 33.00

Research output data provided by the Research Excellence Framework (REF)

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