Enzyme dynamics, design and evolution

A PhD studentship are available to begin in 2022 as part of PREDACTED (https://cordis.europa.eu/project/id/101021207), a European Research Council project based at University of Bristol. This project focuses on computational modelling and simulation for design and engineering of de novo and natural enzymes, and understanding their evolution. This includes molecular simulations of enzyme dynamics and catalysis, and analysis of natural and directed evolution (see e.g. Bunzel et al. Current Opinion in Structural Biology, 2021 https://doi.org/10.1016/j.sbi.2020.12.015). The project will apply a range of computational techniques and also offers the opportunity for interdisciplinary training through close collaboration with biochemical experiments. Applicants should hold a suitable good first degree in Chemistry, Biochemistry or a related discipline by the start of the project.

Contact Prof. Adrian Mulholland (School of Chemistry, [Email Address Removed] ) for further details.

The projects are open to UK applicants; applicants from other countries may also be considered.