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Epigenetic Features of the Genome


Project Description

The lab exploits both chemistry and biology to address fundamental mechanisms of genome function (http://www-balasubramanian.ch.cam.ac.uk). While many genetic determinants of cancer are known, alternative nucleic acid secondary structures and chemically modified DNA (or RNA) bases can be epigenetic features of nucleic acids that are important to normal biology and in oncogenesis. The project will explore chemical modifications as epigenetic features and how these influence secondary structure formation and function in the genome of normal and cancer cells. The scope of the project may include exploring the formation and dynamics of G-quadruplex structures and modified DNA bases in the genome and their roles in gene expression, DNA replication and genome stability. We have developed methods to show that G-quadruplexes are enriched in cancer-related genes and have a profound impact on transcription (e.g. Nature Genetics, 2016, 48, 1267-1272; Nature Biotechnology, 2015, 33, 877-881). We have also developed genome-wide mapping and sequencing of modified bases and are now exploring further base modifications (e.g. Genome Biology, 2017, 18:23; Nature Chemical Biology, 2015, 11, 555-557).

Preferred skills/knowledge
The student will be highly motivated, capable of independent thought and have excellent communication skills with the ability to work collaboratively. Ideally, the candidate will have a strong background in molecular biology and/or biochemistry. Knowledge of the chemistry and biology of nucleic acids would be beneficial.

Please click on ’Visit Website’ for details on how to apply. You must submit an application on-line to be considered for this studentship.

Funding Notes

Funding
This project is funded by a Cancer Research UK studentship that includes full funding for University and College fees and a stipend of £19,000 per annum. The study start date will be October 2020 (Michaelmas term 2020).

Eligibility
No nationality restrictions apply to Cancer Research UK studentships. Applications are invited from recent graduates or final year undergraduates who hold or expect to gain a first/upper second class degree (or equivalent) in a relevant subject from any recognised university worldwide.



How good is research at University of Cambridge in Clinical Medicine?

FTE Category A staff submitted: 192.05

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