SET domain proteins are named after a shared motif in the Drosophila proteins Su(var)3-9, Enhancer-of-zeste and Trithorax, and they form a major branch of the protein lysine methyltransferase enzymes. Their central physiological role is in methylation of histone proteins and regulation of transcription through epigenetic processes. The Schalch lab has a strong interest in deciphering the molecular mechanism and regulation of SET domain proteins and in revealing how they control gene expression. As a PhD student in our lab you will use a combination of protein expression, biochemical assays, X-ray, NMR and cryo-EM structural approaches to reveal the inner workings of SET domain proteins in fundamental biology and cancer aetiology. You will further use the biochemical and structural findings to determine the biological mechanism driving normal cell physiology and disease through functional analysis of targeted mutations in human cells and model organisms.
Academic entry requirements: UK Bachelor Degree with at least 2:1 in a relevant subject or overseas equivalent.