About the Project
We have now developed a novel inducible V(D)J recombination system in which recombination can be activated at will. This project will use the inducible recombination system to examine the safeguards that prevent chromosome translocations during V(D)J recombination. The project will utilize state-of-the-art technologies to give the student first class training in modern molecular, cellular and cancer biology. It will focus on the epigenetic and transcriptional regulation of V(D)J recombination and how errors in this process lead to leukaemia.
Thwaites DT, Carter C, Lawless D, Savic S, Boyes JM. (2019) A novel RAG1 mutation reveals a critical in vivo role for HMGB1/2 during V(D)J recombination. Blood 133, 820-829. doi: 10.1182/blood-2018-07-866939.
Scott JN, Kupinski AP, Kirkham CM, Tuma R, Boyes J. (2014) TALE proteins bind to both active and inactive chromatin. Biochem J. 458:153-8. doi: 10.1042/BJ20131327.
Bevington, S., and Boyes, J., (2013) Transcription-coupled Eviction of histones H2A/H2B governs V(D)J recombination. EMBO J. 32:1381-92
Palacios, D., Summerbell, D., Rigby, P.W.J. and Boyes, J. (2010) Interplay between DNA Methylation and Transcription Factor Availability: Implications for Developmental Activation of the Mouse Myogenin Gene. Molecular and Cellular Biology. 30, 3805-3815.
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